Challenge-dechallenge-rechallenge (CDR) is a medical testing protocol in which a medicine or drug is administered, withdrawn, then re-administered, while being monitored for adverse effects at each stage. The protocol is used when statistical testing is inappropriate due to an idiosyncratic reaction by a specific individual, or a lack of sufficient test subjects and unit of analysis is the individual. During the withdraw phase, the medication is allowed to wash out of the system in order to determine what effect the medication is having on an individual.
目前分類:風聲雨聲讀書聲 (59)
- Mar 14 Sun 2010 12:28
[名詞查詢] rechallenge
- Mar 14 Sun 2010 11:01
[名詞查詢] 6-mercaptopurine
- Mar 14 Sun 2010 09:50
[名詞查詢] Postmarketing surveillance
Postmarketing surveillance (PMS) is the practice of monitoring a pharmaceutical drug or device after it has been released on the market. Since drugs are approved on the basis of clinical trials which involve relatively small numbers of people who have been "controlled" for this purpose - meaning that they normally do not have other medical conditions which may exist in the general population - and postmarketing surveillance can further refine, or confirm or deny, the safety of a drug after it is used in the general population by large numbers of people who have a wide variety of medical conditions.
In the United States, postmarketing surveillance is overseen by the Food and Drug Administration (FDA), which operates a system called MedWatch, to which doctors or the general public can voluntarily report adverse reactions to drugs. [1]
- Mar 12 Fri 2010 00:27
[名詞查詢] A G reverse
中文簡述:A-G reverse、多發性骨髓瘤
- Mar 07 Sun 2010 10:41
[名詞查詢] incretin
- Mar 05 Fri 2010 13:33
[名詞查詢] Morgagni's hernia
(A)aneurysm of aorta
- Mar 03 Wed 2010 21:20
[名詞查詢] intravenous urogram
- Dec 08 Tue 2009 22:36
[名詞查詢] polymyalgia
Polymyalgia (rheumatica) (meaning "pain in many muscles" in Greek), abbreviated as PMR, is an inflammatory condition of the muscles, which causes pain or stiffness, usually in the neck, shoulders, and hips. The pain can be very sudden, or can occur gradually over a period of time.
Most PMR sufferers wake up in the morning with pain in their muscles; however, there have been cases in which the patient has developed the pain during the evenings. Patients who have polymyalgia rheumatica may also have temporal arteritis, a potentially dangerous inflammation of blood vessels in the face. PMR usually goes away within a year or two after treatment.
- Dec 08 Tue 2009 22:26
[名詞查詢] fibromyalgia
- Dec 06 Sun 2009 00:18
[慎勿忘] ASA score
The ASA physical status classification system is a system for assessing the fitness of patients before surgery. In 1963 the American Society of Anesthesiologists (ASA) adopted the five-category physical status classification system; a sixth category was later added. These are:
- A normal healthy patient.
- A patient with mild systemic disease.
- A patient with severe systemic disease.
- A patient with severe systemic disease that is a constant threat to life.
- A moribund patient who is not expected to survive without the operation.
- A declared brain-dead patient whose organs are being removed for donor purposes.
If the surgery is an emergency, the physical status classification is followed by “E” (for emergency) for example “3E”. Class 5 is usually an emergency and is therefore usually "5E". The class "6E" does not exist and is simply recorded as class "6", as all organ retrieval in brain-dead patients are done urgently. The original definition of emergency in 1940, when ASA classification was first designed, was "a surgical procedure which, in the surgeon's opinion, should be performed without delay." This gives an opportunity for a surgeon to manipulate the schedule of elective surgery cases for personal convenience. An emergency is therefore now defined as existing when delay in treatment would significantly increase the threat to the patient's life or body part. With this definition, severe pain due to broken bones, ureteric stone or parturition (giving birth) is not an emergency.
- Nov 13 Fri 2009 08:16
[名詞查詢] bullous edema
: a reddened, swollen appearance of the ureteral orifice in the bladder wall, frequently observed with distal ureteral calculi or in tuberculosis of the ureter.
- Nov 12 Thu 2009 22:46
紫杉醇
最近看到不少化療藥物是使用PAC的病人,而網路上有另一種給法是TAP;兩種給法差的就是cisplatin和carboplatin這一味藥。
- Nov 12 Thu 2009 01:16
Staging of Ovarian Cancer and Cervical Cancer
- Nov 04 Wed 2009 21:12
stain
useful because of its capacity to stain elastic fibers, the metachromatic granules of mast cells, and differentiates smooth muscle from collagen.
- Nov 04 Wed 2009 08:51
[名詞查詢] FIGO stage (endometrial cancer)
The stage of the disease (determined by surgical and pathological findings) and as classified by the International Federation of Obstetricians and Gynaecologists (FIGO).
- Oct 24 Sat 2009 23:58
tocolytics
A 30-year-old G4P0A2E1 female, whose LMP: 2009/4/6 and EDC: 2010/1/14, was admitted for complaining painful uterine contraction. MgSO4 is the first choice for her instead of Yutopar because her blood sugar was over the standard in OPD.
- Oct 11 Sun 2009 17:28
[名詞查詢]Okuda Staging System
Criteria | Positive | Negative |
Tumor size* | >50 percent | <50 percent |
Ascites | Clinically detectable | Clinically absent |
Albumin | <3 mg/dL | >3 mg/dL |
Bilirubin | >3 mg/dL | <3 mg/dL |
Stage | ||
I | No positive | |
II | One or two positives | |
III | Three or four positives |
- Oct 11 Sun 2009 17:15
[名詞查詢]Child Pugh Class
Child-Pugh Score Calculator
- Oct 11 Sun 2009 16:24
[名詞查詢]Seldinger technique
The Seldinger technique is a medical procedure to obtain safe access to blood vessels and other hollow organs. It is named after Dr. SvenIvar Seldinger (1921-1998), a Swedish radiologist from Mora, Dalarna County, who introduced the procedure in 1953.